La verdad es que en aquel momento las formulaciones retardadas empezaban a aparecer y debió ser por eso que una descripcion de tres casos con verapamil, alteraciones del ritmo e insuficiencia renal nos fue admitida en una revista de Nefrologia.

Váquez C(1), Huelmos A, Alegría E, Errasti P, Purroy A.Verapamil deleterious effects in chronic renal failure.1. Nephron. 1996;72(3):461-4.
Three hypertensive patients with chronic renal failure treated with slow-release verapamil at the recommended doses for high blood pressure experienced acute deleterious effects shortly after treatment (6 h to 3 days). Patients developed
slow cardiac rhythms (junctional bradycardia or atrial fibrillation), hypotension and hyperkalemia. Consequently they also had oliguria and worsening of the renal function. Inotropic support, fluid therapy and potassium-lowering measures were
able to restore the renal function and sinus rhythm after 10-12 h. Only 7 similar cases have been described so far. It is suggested that slow-release formulations of verapamil must be used with caution in hypertensive patients with impaired
renal function.

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